Additional loci underscore mechanistic diversity, such as BCL2-associated athanogene 3 (BAG3), a co-chaperon highlighting cytoskeletal disruption, and sodium voltage-gated channel alpha subunit 5 (SCN5A), linking ion channel dysfunction to DCM even without syndromic features [15]. The gene discussed is SCN5A; the disease is familial dilated cardiomyopathy.