PKP2 (truncating/missense) → frequent ARVC substrate [61]. DSP (truncating/missense) → left-dominant with fibrosis [44,60]. TMEM43 p.S358L (missense) → highly malignant, SCD first event [20]. PLN p.Arg14del founder mutation [21]. DES, JUP, DSG2, DSC2 [2]. The gene discussed is TMEM43; the disease is Schnyder corneal dystrophy.