ACTC1 and myopathy: TNNI3 (missense) → ↑ Ca2+ sensitivity, diastolic stiffness [63]. TNNT2 (missense) → restrictive physiology [63]. FLNC (truncating) → restrictive–arrhythmic [22,37]. DES (missense/splice-site) → conduction abnormalities [63]. BAG3 (incl. p.Pro209Leu) → myofibrillar myopathy [23]. Sarcomeric (MYH7, MYBPC3, ACTC1, TPM1, MYPN, MYL2/3) [2]. GLA loss-of-function (Fabry) [64]; TTR missense (ATTRv) [65].