In mouse models, diet-dependent differences were observed: the high-fat diet and ob/ob mice, which model simple hepatic steatosis, showed increased hepatic chemerin mRNA expression, while the Paigen and methionine–choline-deficient (MCD) diets, both inducing NASH with inflammation and fibrosis, led to increased hepatic and, partially, circulating chemerin [52]. This evidence concerns the gene RARRES2 and metabolic dysfunction-associated steatohepatitis.