RARRES2 and esophageal adenocarcinoma: Regarding its role in esophageal adenocarcinoma, chemerin expression increases progressively from metaplastic to dysplastic and invasive stages during the transition from Barrett’s esophagus to adenocarcinoma, likely serving as a chemoattractant for myeloid dendritic cells that drive regulatory T-cell differentiation and suppress anti-tumor immunity, thereby facilitating malignant progression [30].