Subsequent studies provided functional context: Terzoudis et al. [92] associated higher serum chemerin with osteoporosis in IBD, implying a role in extraintestinal metabolic complications, while Sochal et al. [93] observed increased levels during active disease, especially in ulcerative colitis, and normalization following anti-TNF therapy, suggesting responsiveness to inflammatory control. This evidence concerns the gene RARRES2 and irritable bowel syndrome.