Integrating single-cell and spatial transcriptomics, Qi et al. [109] uncovered a chemerin-mediated interaction between FAP+ fibroblasts and SPP1+ macrophages, fostering a desmoplastic, immunosuppressive tumor microenvironment linked to T-cell exclusion, poor survival, and resistance to anti–PD-L1 therapy. Here, RARRES2 is linked to neoplasm.