RARRES2 and colorectal adenoma: In a case–control study, Yagi et al. [100] reported higher serum chemerin levels in men with colorectal adenomas, identifying it as an independent predictor of adenoma presence, while the EPIC-Potsdam cohort linked elevated baseline chemerin with an increased risk of colorectal cancer, particularly in the proximal colon, independent of BMI and inflammatory markers [101].