In Scnn1b-Tg mice, which overexpress the epithelial sodium channel (ENaC) and exhibit cystic fibrosis-like mucus obstruction and inflammation, Siglec-F+ neutrophils were present at baseline in bronchoalveolar lavage and were further recruited during chronic Pseudomonas aeruginosa infection [33]. Here, SCNN1B is linked to cystic fibrosis.