ACE and glomerulosclerosis: Conversely, several proteins with renoprotective or disease-related functions were downregulated, including SERPINA10 (a renoprotective protein), A1BG, angiotensin 1–10 (involved in blood pressure regulation via ACE), APOL1 (associated with glomerulosclerosis and nephrotic syndrome), and AMBP (protective against oxidative stress).