The possibility of reverse inertia should be considered when a patient with T2DM maintains an HbA1c level below 6.5% for more than 12 months and presents with an elevated risk of hypoglycemia—such as in individuals over 75 years of age, those with impaired renal function, or those with dementia or other cognitive impairments—while being treated with insulin or sulfonylureas [86]. The gene discussed is INS; the disease is Hypoglycemia.