Among the most highly significant genes were all those previously reported in the context of the hypermutator phenotype of gastric cancer, including POLD1 (p-value < 10−11), POLE, KMT2C, KMT2A (p-value < 10−8), and MLH1 (p-value < 10−4) (Figure 3, Supplementary Table S3). Here, POLE is linked to gastric cancer.