MTOR and central nervous system cancer: Neuron-specific ribosomal profiling and patch-clamp electrophysiology studies in murine glioma models, demonstrate that neuronal mTOR hyperactivation is implicated in the translational downregulation of both excitatory and inhibitory post-synaptic proteins, loss of dendritic spines, an elevated resting membrane potential, and depolarizing responses to GABAergic stimulation in excitatory neurons [11,113].