Moreover, when looking at the histological manifestations of PbA-infection—hallmarks of ECM—in PKCθ-KO and WT mice, it became apparent that hemorrhagic lesions in the brain were less prevalent and pronounced in the absence of PKCθ (Figure 2a) in H&E-stained brain sections at day 6 p.i. Both the number (Figure 2b) and size (Figure 2c,d) of lesions were markedly reduced in PKCθ-KO animals compared to WT mice. Here, PRRT2 is linked to infection.