Nutritional and hormonal signals converge on MTP; for instance, high-fat, high-carbohydrate diets enhance hepatic TG synthesis and intracellular Ca2+ levels, both of which proportionally elevate MTP activity and VLDL output, ultimately leading to hypertriglyceridemia and hypercholesterolemia [9,10]. The gene discussed is MTTP; the disease is Hypercholesterolemia.