Plasma IL-6 in the overall population had a good diagnostic performance with an AUC = 0.79 (95% CI: 0.76–0.83), similar to that for the PTL and PPROM subgroups, with a sensitivity of 72% (95% CI: 0.58–0.83) and a specificity of 79% (95% CI: 0.72–0.84). The gene discussed is IL6; the disease is preterm premature rupture of the membranes.