The pro-oncogenic snoRNA SNORA42 activates the NF-κB signaling pathway by mediating the interaction between the DHX9 and p65 subunits, leading to the upregulation of downstream target genes (including MMP2, MMP9, VEGF, and BCL2) and thereby driving tumor proliferation, invasion, and angiogenesis [135]. The gene discussed is NFKB1; the disease is neoplasm.