Both miRNAs regulate genes central to neuronal excitability, synaptic dysfunction, and neuroinflammation, which are core mechanisms underlying epilepsy and CDD [9,71,100,101,102,103], although none of the specific targets are clearly reported yet as established, validated downstream effectors of CDKL5 in CDD [17,104,105,106,107,108,109]. Here, CDKL5 is linked to epilepsy.