Melanoma Cell Lines Following hnRNPH2 siRNA-mediated knockdown. To determine whether IFN signaling induction by hnRNPH2 siRNA treatment is also observed in other melanoma cell lines, we also included A375, WM266-4 (BRAF-mutant), WM1366 (NRAS-mutant), and WM3918 (triple-wild-type, TWT) in our experiments. This evidence concerns the gene NRAS and melanoma.