A domain of an SLP, termed the micro integral membrane protein (MIMP), isolated from L. plantarum CGMCC1258, significantly reduced inflammation in DSS-induced colitis mice by decreasing IFN-γ, IL-17, and IL-23 while increasing IL-4 and IL-10, and was also found to improve the health status of these mice, while at the same time reducing IFN-γ, IL-17, and IL-23 levels and up-expressing IL-4 and IL-10 levels compared to the mice who did not receive MIMP treatment [234]. The gene discussed is IFNG; the disease is colitis.