Notably, there is a substantial overlap with the MmD results, with 20 KEGG pathways shared between the two analyses (including antigen processing and presentation, allograft rejection, IL-17 signalling, insulin signalling, oxidative phosphorylation, and Wnt signalling), 12 were shared between the all-RYR1-RM and CCD analyses, and 6 were common to all 3 (oxidative phosphorylation, cardiac muscle contraction, wnt signalling pathway, IL-17 signalling pathway, pathways in cancer, breast cancer), underscoring common molecular mechanisms underlying the RYR1-RM disease spectrum (Table S14). This evidence concerns the gene INS and cancer.