SLE monocytes also display a senescent program marked by increased cyclin-dependent kinase inhibitor 2A (CDKN2A), which induces GATA-binding protein 4 (GATA4) and augments IFN-α production via activation of the cGAS–STING pathway, thereby linking cellular aging to inflammation [283]. This evidence concerns the gene IFNA2 and systemic lupus erythematosus.