This cross-talk between signaling pathways is particularly relevant in cryptorchidism-induced testicular dysfunction, as demonstrated by Yadav et al., who reported that chronic unpredictable stress disrupts testicular function by perturbing the Nrf2/HO-1/IKKβ/NF-κB oxido-inflammatory pathway [54]. This evidence concerns the gene HMOX1 and cryptorchidism.