It was proved that PRMT5 has a regulatory site at the Thr80 amino acid residue, which, when phosphorylated by Rho A activated kinase (ROK), increases activity, but dephosphorylation by myosin phosphatase (MP)-consisting of a protein phosphatase 1 catalytic subunit (PP1c) and a MYPT1 regulatory subunit [27]-decreases PRMT5 activity in hepatocellular carcinoma cells [28]. This evidence concerns the gene PRMT5 and hepatocellular carcinoma.