METTL14 and familial pancreatic carcinoma: Although METTL14 promotes metastasis by increasing m6A on PERP mRNA in pancreatic cancer metastasis, it often acts as a metastasis suppressor in colorectal and hepatocellular carcinoma, where loss of METTL14 leads to EMT and stemness through reduced m6A abundance on key transcripts [71,77,82].