Hepatocellular carcinoma provides an additional illustration in which circHPS5 accumulates with increased m6A; METTL3 facilitates circHPS5 production, YTHDC1 supports cytoplasmic export, and circHPS5 functions as a miRNA sponge that elevates HMGA2 expression and promotes malignant phenotypes aligned with invasion and colonization [182]. The gene discussed is METTL3; the disease is hepatocellular carcinoma.