Additional genetic markers under investigation include variants in genes involved in lipid metabolism (e.g., APOE, LIPC), extracellular matrix regulation (e.g., TIMP3), and angiogenic signaling pathways (e.g., VEGFA), further expanding the landscape of genetic risk assessment in AMD [126,127,128] (Figure 2B). This evidence concerns the gene VEGFA and age-related macular degeneration.