Inflammation-driven models such as CC chemokine ligand 2 (Ccl2)−/−, C-X3-C Motif Chemokine Receptor 1 (Cx3cr1)−/−, and Ccl2−/−Cx3cr1−/− replicate aspects of dry AMD by exhibiting subretinal microglial accumulation, upregulation of pro-inflammatory cytokines, and complement activation [39,40,41]. The gene discussed is CCL2; the disease is dry age related macular degeneration.