Experimental studies carried out to investigate the significance of such enzyme overexpression, as well as the impact of NNMT dysregulation on tumor cell phenotype, clearly demonstrated that NNMT positively influences fundamental events promoting and sustaining carcinogenesis, such as cell proliferation, migration, invasiveness, apoptosis inhibition and cell cycle progression, together with chemo and radioresistance [17,18,19,20,21,22,23], strongly supporting the hypothesis that the enzyme may have great potential as a molecular target for effective anticancer treatment. This evidence concerns the gene NNMT and neoplasm.