or fermentation substrates (dietary fibers) aims to enrich SCFA-producing taxa that both (a) downregulate tumor antioxidant defenses (GPX4/SLC7A11) and (b) favor DC maturation and CD8+ T-cell priming—thereby lowering tumor ferroptosis thresholds while augmenting antitumor immunity [106,107]. The gene discussed is SLC7A11; the disease is neoplasm.