NOS3 and type 2 diabetes mellitus: In other studies using a db/db T2DM mouse model, reduced endothelial-dependent relaxation responses and Ser1177 phosphorylation of eNOS in mesenteric resistance arteries isolated from T2DM mice were observed alongside increased p22phox expression and increases in p38 MAPK and ERK1/2 phosphorylation and activation [95].