For AT1R inhibition, polyphenols such as rosmarinic acid and quercetin bind to AT1R with high affinity, effectively blocking AngII-mediated pro-tumor signaling [83,116], which mirrors the effects of RASi (e.g., losartan) observed in bladder cancer and TNBC [118,122]. Here, AGTR1 is linked to urinary bladder carcinoma.