In summary, polyphenols achieve a dynamic balance of the RAS dual-axis by inhibiting the excessive activation of the classical axis (ACE/AngII/AT1R axis), through the reduction in renin, ACE, and AT1R activity, while simultaneously enhancing the protective axis (ACE2/Ang(1-7)/MasR axis) by upregulating ACE2, Ang(1-7), and MasR, thereby alleviating hypertension, tumors, cardiovascular diseases, and other pathological conditions. This evidence concerns the gene ACE2 and hypertensive disorder.