Moreover, regarding anti-tumor activity, the ACE2/Ang-(1-7)/MasR axis collaborates with AT2R to establish a protective axis that inhibits tumor growth, angiogenesis, and metastasis by downregulating pro-tumor pathways, such as ERK and PI3K/Akt, associated with the classical RAS axis (ACE/AngII/AT1R). This evidence concerns the gene AKT1 and neoplasm.