Due to variants such as rs148110342, which have been related to high enzymatic activity, they are significantly associated with type 2 diabetes and changes in LDL cholesterol levels in Kawaii populations [14], and hypermethylation in two of the eight CpG sites tested in the FURIN promoter was associated with an increased risk of diabetes in Chinese populations in Gusu [15]. Here, FURIN is linked to type 2 diabetes mellitus.