FURIN and central nervous system cancer: In other important clinical implications, the rs4702-A allele was associated with higher expression of FURIN and BDNF in the serum of glioma patients after radiotherapy, implying a lower risk of radiotherapy-induced cognitive impairment [16], and the negative regulation of FURIN expression by miR-338-3p, specific to the rs4702 G allele, is associated with schizophrenia [17].