Resistin, another pro-inflammatory adipokine, is primarily secreted by macrophages and has been shown to activate the NF-κB pathway through binding to its receptor Adenylyl Cyclase-Associated Protein 1 (CAP1), thereby exacerbating insulin resistance and promoting endothelial dysfunction characterized by reduced nitric oxide bioavailability and increased production of vasoconstrictive agents [36]. The gene discussed is CAP1; the disease is endothelial dysfunction.