Sambucus nigra agglutinin (SNA) chromatography indicated elevated Fab variable domain glycosylation (VDG) levels in anti-Smith and anti-dsDNA antibodies from patients with systemic lupus erythematosus (SLE), but not in the less disease-specific anti-Ro52 antibodies [30]. The gene discussed is TRIM21; the disease is systemic lupus erythematosus.