Xin et al. (2025) have shown that in cerebral ischemia exacerbated by hyperglycemia, reduced levels of SIRT1/SIRT3 are responsible for an increase in ROS activity and an increase in the inflammatory cascade (presented by elevation of IL-1β, IL-6, and TNF-α) [66]. The gene discussed is SIRT1; the disease is Hyperglycemia.