Sood et al. (2023) recently revealed that FTY720 supplementation of T2DM mice for 30 days alleviates cognitive deficit in T2DM mice by promoting microglial M2 polarization via the pSTAT3-jmjd3 axis, and this effect was independent of blood glucose control [78]. The gene discussed is KDM6B; the disease is type 2 diabetes mellitus.