CEACAM5 and neoplasm: Multi-cancer screening platforms, such as OneTest, combine tumor-associated proteins (AFP, CEA, CA19-9, CA125, CA15-3, PSA, CYFRA 21-1) with clinical variables and employ models including SVM, k-nearest neighbors, Ridge Logistic Regression, MLP, and J48 decision trees to detect over 20 cancer types [140].