The results revealed clusters associated with aortic aneurysm and elastic fiber formation (LOXL1, FBN1, CD248, TIMP2, MFAP5, SMAD3, SERPINE2, TGFBI, and COPZ2) and DNA methylation (MAPRE3, H2BC21, DNMT3B, and ASPH) in the SMC vs. non-SMC comparison based on limma. The gene discussed is MFAP5; the disease is aortic aneurysm.