The results revealed clusters associated with aortic aneurysm and elastic fiber formation (LOXL1, FBN1, CD248, TIMP2, MFAP5, SMAD3, SERPINE2, TGFBI, and COPZ2) and DNA methylation (MAPRE3, H2BC21, DNMT3B, and ASPH) in the SMC vs. non-SMC comparison based on limma. This evidence concerns the gene SMAD3 and aortic aneurysm.