In the SMC-calc vs. SMC comparison based on limma, clusters related to high-density lipoprotein (HDL) assembly (PF4V1, APOA1, LPXN, AFP, A2M, and MMP1) and amyloidosis (CX3CL1, APOE, PLIN3, TGFBI, and CH25H) were identified. The gene discussed is APOE; the disease is amyloidosis.