To explore the synergistic benefit of [177Lu]Lu-PSMA-617 and surgery, men with high-risk localised PCa were given upfront [177Lu]Lu-PSMA-617 prior to radical prostatectomy in the LuTectomy study, demonstrating low rates of BCR and low rates of adverse events on follow-up [21,42]. Here, FOLH1 is linked to posterior cortical atrophy.