Given that PSMA is expressed on the endothelial cells of tumour neovasculature, these angiogeneic pathways may be exploited to amplify and concentrate ligand delivery, explaining the strong uptake in highly vascular tumours such as renal cell carcinoma (RCC) and glioblastoma multiforme (GBM). Here, FOLH1 is linked to hereditary clear cell renal cell carcinoma.