Ewing sarcoma cells appear to be heterogeneous with prior studies demonstrating different levels of EWS;FLi1 transcripts in different states of cell cycle and sparse activation of nuclear beta-catenin in clinical samples, so our work highlights the importance of understanding non-canonical Wnt signaling in the context of the earliest steps in the metastatic cascade migration. The gene discussed is FLI1; the disease is Ewing sarcoma.