Thus, in further evaluation of the early steps of metastasis in Ewing sarcoma, we have identified a non-canonical beta-catenin-independent Wnt signaling pathway, dependent on autocrine/paracrine Wnt5a and involving FAK, Src, and ALCAM, that drives migration of Ewing sarcoma cells through formation of focal adhesions. The gene discussed is CTNNB1; the disease is Ewing sarcoma.