RBP2 exhibited significant downregulation across several tumors, including KICH, KIRC, KIRP, LUAD, LUSC, and thyroid carcinoma (THCA), with elevated expression observed in breast invasive carcinoma (BRCA), cholangiocarcinoma (CHOL), colon adenocarcinoma (COAD), and LIHC (Figure 1B). The gene discussed is RBP2; the disease is cholangiocarcinoma.