The expression of the pluripotency protein NANOG in the VHL-corrected ccRCC line indicates the initial colonies we achieved are in an intermediate reprogramming state [64], and despite the presence of a WT VHL gene, the cells are retaining some of their tumor cell properties and cannot fully transition to a pluripotent state due to other mutated genes that contribute to ccRCC. The gene discussed is VHL; the disease is neoplasm.