PPARGC1A and nonpapillary renal cell carcinoma: In ccRCC cells, during cellular respiration, HIF’s initiate glycolysis and in parallel downregulate mitochondrial oxidative phosphorylation (OXPHOS) through the transcriptional downregulation of PGC1α, resulting in the characteristic energy map of ccRCC (Warburg effect) [52,53,54,55].