HCAR1 and posterior cortical atrophy: A number of mARs have been identified—including GPR133 (ADGRD1), an adhesion GPCR (aGPCR) encoded by HCaR1, which binds to 5α-dihydrotestosterone (5α-DHT); ZIP9 (SLC39A9), a zinc transporter protein that influences apoptosis in PCa; GPRC6A, a GPCR expressed in PCa that is activated by L-α-amino acids and is modulated by calcium; OXER1, an oxoeicosanoid receptor expressed in PCa that binds testosterone and inhibits cell proliferation and migration; and TRPM8, an ion channel/transporter that is regulated by androgens [32].