In contrast, RhoC is unambiguously an oncogene with a twist—it has little effect on tumor growth or proliferation but instead plays an oversized role in metastasis in PCa by sequential activation of Pyk2, FAK, MAPK, and Akt, followed by the upregulation of MMP2 and MMP9 [76]. The gene discussed is RHOC; the disease is posterior cortical atrophy.