In contrast, RhoC is unambiguously an oncogene with a twist—it has little effect on tumor growth or proliferation but instead plays an oversized role in metastasis in PCa by sequential activation of Pyk2, FAK, MAPK, and Akt, followed by the upregulation of MMP2 and MMP9 [76]. This evidence concerns the gene AKT1 and posterior cortical atrophy.