In melanoma, upregulation of miR-155-5p suppresses SOCS1 expression, leading to JAK2/STAT3 pathway activation and overexpression of matrix metalloproteinase-9 (MMP9), VEGFa and FGF2 factors, ultimately enhancing angiogenesis, proliferation and migration [93] and in ovarian cancer, upregulation of miR-29c-3p suppresses migration and invasion by directly targeting MMP2 [94]. The gene discussed is MMP9; the disease is ovarian cancer.