For instance, the upregulation of miR-96-5p in renal cell carcinoma downregulates PTEN expression and increases cell proliferation [82], while the upregulation of miR-449a downregulates mutant p53 expression, which decreases cell proliferation in breast cancer, through inactivation of the PI3K/Akt pathway [83]. This evidence concerns the gene PIK3CA and breast carcinoma.