MADD and leukemia: In this context, Otmani et al. [74] reported that exosome-derived miR-24-3p promotes T-cell apoptosis in leukemia via DENN/MADD regulation, and Zhao et al. [75] demonstrated that exosome-derived miR-934 from colorectal cancer cells enhances the PI3K/Akt signaling pathway, promoting M2 macrophage polarization.