An ICPC/Cell study of HBV-related HCC (n = 159) resolved proteome subclasses (metabolism, proliferation, microenvironment) and highlighted discordance between mRNA and protein, with metabolism and kinase signalling (e.g., AKT–mechanistic target of rapamycin [mTOR]) reprogrammed at the protein/phosphoprotein level [32]. The gene discussed is MTOR; the disease is hepatocellular carcinoma.