ITK and clear cell renal carcinoma: Similarly to the data from Nakagawa et al., Zamora-Fuentes et al. found ITK to be hypomethylated in all stages of clear cell renal cancer, classifying ITK as methylation-related oncogene; however, contrary to Carson et al., Zamora-Fuentes’ data shows that the cohort with higher expressions of ITK has a more favourable OS [40].