MYC mutations occurred significantly more frequently in breast (n = 35 vs. n = 0, p = 1.375e-3) than liver angiosarcomas, while RPTOR (n = 2 vs. n = 1, p = 0.0408) and TP53 (n = 4 vs. n = 9, p = 0.0456) mutations occurred more frequently in liver than breast angiosarcomas. Here, TP53 is linked to liver angiosarcoma.