Mutations in ZFHX4 (p = 0.0392), FGFR1 (p = 0.0436), MSI2 (p = 0.0437), HIST1H1C (p = 0.0467), and TOP1 (p = 0.0497) were significantly more common in metastatic tumors compared to primary tumors. This evidence concerns the gene TOP1 and metastatic neoplasm.