We also observed significant co-occurrence of FAT1-NOTCH2, ARID1A-NOTCH, and ARID1A-NOTCH2, suggesting potential interactions between Notch signaling, FAT1 signaling (Hippo, Wnt), and ARID1A (chromatin remodeling) in angiosarcoma pathogenesis; these gene alterations have been identified in prior studies as well [15,27,34,45,47]. The gene discussed is NOTCH2; the disease is angiosarcoma.