The matrix protein fibulin 3 favors kisspeptin 1 receptor-induced triple-negative BC cell invasion: the fibulin 3 gene is amplified in these cells; the plasma fibulin 3 level is higher in patients with triple-negative BC than in healthy individuals; and the activation of the kisspeptin 1 receptor augmented both the release and expression of fibulin 3 [115]. This evidence concerns the gene EFEMP1 and breast cancer.