TAC1 and breast cancer: Moreover, in a review focused on the involvement of the substance P/neurokinin receptor 1 system in triple-negative BC, the authors concluded that neurokinin receptor 1 antagonists, including aprepitant, exerted antiproliferative, antimetastatic and apoptotic effects against triple-negative BC cells overexpressing neurokinin receptor 1 and, in addition, these antagonists decreased the tumor volume of triple-negative BC cells in experimental animals [229].