KP-10, via the activation of the Smad signaling pathway, blocked the Warburg effect and favored mitochondrial injury in MDA-MB-231 BC cells and, compared with non-cancerous tissues, mRNA and protein levels of pyruvate dehydrogenase kinase, pyruvate kinase and hexokinase 2 were higher in BC tissues [128]. The gene discussed is HK2; the disease is breast cancer.