Moreover, neurokinin A promoted the migration and invasion of BC cells and hence augmented the aggressiveness of metastatic BC cells [178]; it increased the expression of neurokinin receptors 1 and 2 in metastatic BC cells and favored the secretion of a bradykinin precursor (high-molecular-weight kininogen compound) that mediates tumorigenic effects [178]. This evidence concerns the gene TAC1 and breast cancer.