Chen et al. demonstrated that miRNA-495-3p inhibits the HSPA5-mediated activation of macroautophagic receptor Sequestosome 1 (SQSTM1)/p62 in gastric cancer [104] and inhibits the HSPA5-mediated ubiquitination of the mitochondrial ubiquitin ligase activator of NFκB 1 (MUL1), thereby suppressing autophagosome formation and mediating multidrug resistance. Here, SQSTM1 is linked to gastric cancer.