The PERK-dependent activation of C/EBPδ creates prolonged activation of CXCL8 (also known as IL-8) and CCL20 [154], two well-known tumor-promoting chemokines that have been shown to recruit regulatory T cells and polarize macrophages into immunosuppressive M2 phenotypes [155,156]. Here, EIF2AK3 is linked to neoplasm.