HSPA5 and neoplasm: In gastric cancer, the inhibition of HSPA5 via betulinic acid decreases HSPA5-dependent TGF-β secretion, leading to a decrease in the expression of stemness markers, CD44 and OCT4 [100,101,102], and interleukin 6 (IL6) secretion, and polarization of macrophages from the immunosuppressive M2 phenotype to anti-tumor M1 phenotype [103].