EIF2A and steatosis: Deliberate dephosphorylation (and, hence, the attenuation of eIF2α activity) of eIF2α via the overexpression of eIF2α phosphatase (GADD34-overexpression) has been shown independently to suppress the lipogenesis (and steatosis) transcriptional regulator Peroxisome Proliferator-Activated Receptor (PPAR), and C/EBPα and C/EBPβ, with the phosphorylation of eIF2α promoting C/EBP expression [172].