In different cancers, the presence of Th2 cells in the tumor immune microenvironment can induce the polarization of anti-tumor immunostimulatory M1 macrophages to pro-tumor immunosuppressive M2 macrophages [137] via IL-5 and IL-13, and can suppress the infiltration of CD8+ T cells [138], thereby promoting tumor growth. This evidence concerns the gene IL13 and neoplasm.