In triple-negative breast cancer, the inhibition of IRE1α RNAse is shown to increase levels of triacylglycerols (TAGs) and polyunsaturated fatty acids, and to lower levels of diacylglycerols (DAG) while upregulating sterol regulatory element-binding transcription factor 1 (SREBF1), Diacylglycerol O-acyltransferase 2 (DGAT2), and Lipase E (LIPE) genes, hinting at a pivotal role of IRE1α in suppressing TAG biosynthesis. Here, DGAT2 is linked to triple-negative breast carcinoma.