PIK3CA and triple-negative breast carcinoma: In contrast, breast AciCCs lack NR4A3 rearrangement and overexpression, and their molecular profile is instead characterized by frequent mutations in TP53 and PIK3CA, as well as complex patterns of copy number alterations, closely resembling those seen in conventional triple-negative breast cancers rather than salivary gland AciCC [19,98,103,104].