This upregulation of inhibitory receptors, including LAG-3, TIGIT, and Tim-3, in addition to, and sometimes in combination with, PD-1 [21,34,57,58,59,60], can impair effective anti-tumor immune responses and may partially explain the reduced CD8+ T cell infiltration observed in biopsies from patients with advanced disease. This evidence concerns the gene HAVCR2 and neoplasm.