The tumor microenvironment was highly immunosuppressive: T cells expressing multiple checkpoints were more likely to be found in the tumor than in peripheral blood mononuclear cells (PBMC)s, up to 6-fold higher in the case of PD-1+ NKG2A+ cells, highlighting the importance of examining biopsies, not only peripheral blood, for exhausted T cell signatures that may be key to cancer diagnosis and management. The gene discussed is KLRC1; the disease is cancer.