Both in terms of the analysis of TILs and of immunohistochemistry, the crucial role of multiple immune checkpoints, including PD-1, TIGIT, TIM-3, LAG-3, BTLA, and NKG2A, in driving CD8+ T cell exhaustion in cervical cancer becomes clearer when focusing on the transformed tissue and infiltrating cells. This evidence concerns the gene TIGIT and cervical cancer.