High levels of oxidative stress were manifested by high expression of its marker genes: SLC7A11 (a cystine and glutamate transporter, often upregulated in cancer), NQO1 (an antioxidant that reduces reactive quinones and stabilizes p53), and HSPA1A (a heat shock protein that stabilizes protein folding and is involved in the degradation of abnormal proteins). The gene discussed is SLC7A11; the disease is cancer.