While not all the 14 variants identified in our study have a clear link to MM/MGUS (REPS1, THEMIS, TAAR6, LAMA2, MTFR2/FAM54A), several (AHI1, VNN1, VNN3, PHACTR2) have had reported functional relevance in hematopoiesis and etiology of hematologic malignancies. Here, THEMIS is linked to hematologic disorder.