Mucin-1 (MUC-1), epithelial cell adhesion molecule (EpCAM) and cluster of differentiation 147 (CD147) are expressed on the surface of HCC cells [114,115,116] and CAR-T cells for these two molecules are being evaluated in multiple clinical trials, such as NCT02587689, NCT03013712, NCT02729493 and NCT03993743, the results of which are yet to be determined. This evidence concerns the gene EPCAM and hepatocellular carcinoma.