Therefore, it is important not to synchronize the collagenolytic aMMP-8 with non-collagenolytic total, or latentpro-MMP-8 forms in periodontitis and peri-implant diagnostics, as tMMP-8 levels may reflect non-pathological states [62,63,64,66,67,69,73,83]. The gene discussed is MMP8; the disease is periodontitis.