In peripartum cardiomyopathy, cleavage of prolactin into its 16 kDa fragment exerts toxic anti-angiogenic effects, while in pre-eclampsia, overexpression of sFlt-1 disrupts VEGF- and PlGF-mediated endothelial repair [14,32]. The gene discussed is PGF; the disease is peripartum cardiomyopathy.