CD8A and neoplasm: Prospective radiopathologic correlation—including quantification of percentage necrosis, fibrosis, and viable tumor cellularity on resection/biopsy, digital-pathology assessments (e.g., collagen content and CD8+ density), and circulating tumor DNA kinetics—together with radiogenomic analyses will be prioritized to elucidate the microstructural and molecular underpinnings of Δ-GLCM Homogeneity.