PITX2 and diabetes mellitus: Polymorphisms MTHFR, PITX2 and KCNE1, tHcy, age, sex, and folate concentrations were considered as individual variables, while others were submitted to PCA to identify five components: “Blood pressure”, “Lipid”, “Renal-BNP”, “Diabetes” (pre-existing diabetes, fasting glucose), and “BMI-CRP” (body mass index category, CRP, and current smoking) (details in Supplementary Material D, Figure S4).